Sparse multidimensional exponential analysis with an application to radar imaging

We present a d-dimensional exponential analysis algorithm that offers a range of advantages compared to other methods. The technique does not suffer the curse of dimensionality and only needs O((d + 1)n) samples for the analysis of an n-sparse expression. It does not require a prior estimate of the sparsity n of the d-variate exponential sum. The method can work with sub-Nyquist sampled data and offers a validation step, which is very useful in low SNR conditions. A favourable computation cost results from the fact that d independent smaller systems are solved instead of one large system incorporating all measurements simultaneously. So the method also lends itself easily to a parallel execution. Our motivation to develop the technique comes from 2D and 3D radar imaging and is therefore illustrated on such examples

Active inductor shunt peaking in high-speed VCSEL driver design

An all transistor active inductor shunt peaking structure has been used in a prototype of 8-Gbps high-speed VCSEL driver which is designed for the optical link in ATLAS liquid Argon calorimeter upgrade. The VCSEL driver is fabricated in a commercial 0.25-um Silicon-on-Sapphire (SoS) CMOS process for radiation tolerant purpose. The all transistor active inductor shunt peaking is used to overcome the bandwidth limitation from the CMOS process. The peaking structure has the same peaking effect as the passive one, but takes a small area, does not need linear resistors and can overcome the process variation by adjust the peaking strength via an external control. The design has been tapped out, and the prototype has been proofed by the preliminary electrical test results and bit error ratio test results. The driver achieves 8-Gbps data rate as simulated with the peaking. We present the all transistor active inductor shunt peaking structure, simulation and test results in this paper.Comment: 4 pages, 6 figures and 1 table, Submitted to 'Chinese Physics C

New g'r'i'z' Photometry of the NGC 5128 Globular Cluster System

We present new photometry for 323 of the globular clusters in NGC 5128 (Centaurus A), measured for the first time in the $g'r'i'z'$ filter system. The color indices are calibrated directly to standard stars in the $g'r'i'z'$ system and are used to establish the fiducial mean colors for the blue and red (low and high metallicity) globular cluster sequences. We also use spectroscopically measured abundances to establish the conversion between the most metallicity-sensitive colors ($(g'-r')_0$, $(g'-i')_0$) and metallicity, [Fe/H].Comment: 14 pages, 9 figures, accepted in A

HIMA2: High-dimensional mediation analysis and its application in epigenome-wide DNA methylation data

Mediation analysis plays a major role in identifying significant mediators in the pathway between environmental exposures and health outcomes. With advanced data collection technology for large-scale studies, there has been growing research interest in developing methodology for high-dimensional mediation analysis. In this paper we present HIMA2, an extension of the HIMA method (Zhang in Bioinformatics 32:3150-3154, 2016). First, the proposed HIMA2 reduces the dimension of mediators to a manageable level based on the sure independence screening (SIS) method (Fan in J R Stat Soc Ser B 70:849-911, 2008). Second, a de-biased Lasso procedure is implemented for estimating regression parameters. Third, we use a multiple-testing procedure to accurately control the false discovery rate (FDR) when testing high-dimensional mediation hypotheses. We demonstrate its practical performance using Monte Carlo simulation studies and apply our method to identify DNA methylation markers which mediate the pathway from smoking to reduced lung function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy

The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-proteasome system and autophagy but how they are molecularly coordinated is not well understood. Here, we demonstrate an essential role for an effector caspase in the activation of compensatory autophagy when proteasomal activity is compromised. Functional loss of Hsp83, the Drosophila ortholog of human HSP90 (heat shock protein 90), resulted in reduced proteasomal activity and elevated levels of the effector caspase Dcp-1. Surprisingly, genetic analyses showed that the caspase was not required for cell death in this context, but instead was essential for the ensuing compensatory autophagy, female fertility, and organism viability. The zymogen pro-Dcp-1 was found to interact with Hsp83 and undergo proteasomal regulation in an Hsp83-dependent manner. Our work not only reveals unappreciated roles for Hsp83 in proteasomal activity and regulation of Dcp-1, but identifies an effector caspase as a key regulatory factor for sustaining adaptation to cell stress in vivo

Decomposing Textures Using Exponential Analysis

Decomposition is integral to most image processing algorithms and often required in texture analysis. We present a new approach using a recent 2-dimensional exponential analysis technique. Exponential analysis offers the advantage of sparsity in the model and continuity in the parameters. This results in a much more compact representation of textures when compared to traditional Fourier or wavelet transform techniques. Our experiments include synthetic as well as real texture images from standard benchmark datasets. The results outperform FFT in representing texture patterns with significantly fewer terms while retaining RMSE values after reconstruction. The underlying periodic complex exponential model works best for texture patterns that are homogeneous. We demonstrate the usefulness of the method in two common vision processing application examples, namely texture classification and defect detection

Development of A 16:1 serializer for data transmission at 5 Gbps

Radiation tolerant, high speed and low power serializer ASIC is critical for optical link systems in particle physics experiments. Based on a commercial 0.25 μm silicon-onsapphire CMOS technology, we design a 16:1 serializer with 5 Gbps serial data rate. This ASIC has been submitted for fabrication. The post-layout simulation indicates the deterministic jitter is 54 ps (pk-pk) and random jitter is 3 ps (rms). The power consumption of the serializer is 500 mW. The design details and post layout simulation results are presented in this paper

High-Speed Serial Optical Link Test Bench Using FPGA with Embedded Transceivers

We develop a custom Bit Error Rate test bench based on Altera’s Stratix II GX transceiver signal integrity development kit, demonstrate it on point-to-point serial optical link with data rate up to 5 Gbps, and compare it with commercial stand alone tester. The 8B/10B protocol is implemented and its effects studied. A variable optical attenuator is inserted in the fibre loop to induce transmission degradation and to measure receiver sensitivity. We report comparable receiver sensitivity results using the FPGA based tester and commercial tester. The results of the FPGA also shows that there are more one-tozero bit flips than zero-to-one bit flips at lower error rate. In 8B/10B coded transmission, there are more word errors than bit flips, and the total error rate is less than two times that of non-coded transmission. Total error rate measured complies with simulation results, according to the protocol setup